孙冬冬  
性    别:
单    位:
澳门赌搏网站大全
专业名称:
生物制药
研究方向:
纳米药物的设计与活性研究
技术职务:
副教授
行政职务:
生物制药系副主任
办公电话:
办公传真:
 E-mail:
sunddwj126.com
实验室主页:
通讯地址:
澳门赌搏网站大全
邮政编码:
230036
孙冬冬,男,博士,硕士生导师。2013年进入澳门赌搏网站大全工作。主要研究方向为小分子配合物的生物活性及其调控细胞信号转导途径的功能;纳米药物的制备、缓释控制及其靶向功能的研究与应用;具有抗肿瘤、阿尔茨海默氏病、抗菌活性的化学新药研制与开发。主持国家自然科学基金青年科学基金项目、安徽省自然科学基金青年科学基金项目。在金属小分子的设计与开发,纳米修饰,分子成像以及癌症治疗领域研究有着丰富的研究经验,并取得了较好的研究成果,以第一编辑身份发表SCI收录论文17余篇,其中包括Biomaterials(IF=8.4),Applied Materials&Interfaces(IF=7.1)Chemistry A European Journal(IF=5.8)和Dalton Trans(IF=4.0)等高水平学术论文。
 主讲课程
药物化学、药物分析及药事管理学。
 
 科研情况
(1)国家自然科学基金青年科学基金项目(2014-2017年)手性青霉胺纳米多肽抑制金属离子诱导的Aβ纤维化聚集及机制研究  编号:21401002  主持  25万
(2)安徽省自然科学基金青年科学基金项目(2015-2017年)  编号:1508085QB37  主持  8万
 获奖情况
安徽省道地中药材系列品种选育与应用  2016年安徽省科学技术奖三等奖 (主要项目完成人)
 论文论著
  1. Dongdong Sun1, Weiwei Zhang1, Zhipeng Mou, Ying Chen, Feng Guo, Endong Yang, Weiyun Wang* Transcriptome Analysis Reveals Silver Nanoparticle-decorated Quercetin Antibacterial Molecular Mechanism. Applied Materials&Interfaces. 2017, DOI: 10.1021/acsami.7b02380. IF=8.09  SCI一区  引用12次
  2. Dongdong Sun, Yanan Liu, Qianqian Yu, Qiuying Qin, Licong Yang, Yanhui Zhou, Lanmei Chen, Jie Liu*. Inhibition of tumor growth and vasculature and fluorescence imaging using functionalized ruthenium-thiol protected selenium nanoparticles. Biomaterials 2014, 35, 1572-1583. IF=8.4  SCI一区  引用52次
  3. Dongdong Sun, Yanan Liu, Qianqian Yu, Yanhui Zhou, Rong Zhang, Xiaojia Chen, An Hong* and Jie Liu*. The Effects of Luminescent Ruthenium(II) Polypyridyl Functionalized Selenium Nanoparticles on bFGF-induced Angiogenesis and AKT/ ERK Signaling. Biomaterials, 34 (2013) 171-180. IF=8.4  SCI一区  引用56次
  4. Dongdong Sun, Yanan Liu, Du Liu, Rong Zhang, Xicheng Yang,and Jie Liu*. Stabilization of G-Quadruplex DNA, Inhibition of Telomerase Activity and Live Cell Imaging Studies of Chiral Ruthenium(II) Complexes. Chem. Eur. J. 2012, 18, 4285-4295. IF=5.8  SCI一区  引用95次
  5. Dongdong Sun, Rong Zhang, Fang Yuan, Du Liu, Yanhui Zhou, Wenjie Mei, and Jie Liu*. Studies on characterization, telomerase inhibitory property and G-quadruplex binding of η6-arene ruthenium complexes with 1,10-phenanthroline-derived ligands. DaltonTrans 2011;41:1734-41. IF=4.0  SCI一区   引用24次
  6. Dongdong Sun, Nuan Li, Weiwei Zhang, Zhiwei Zhao, Zhipeng Mou, Donghui Huang, Jie Liu, Weiyun Wang*. Design of PLGA- functional quercetin nanoparticles for potential use in Alzhermer' disease Colloid Surface B.148(2016)116-129.IF: 3.902  SCI一区  引用4次
  7. Dongdong Sun, Yanan Liu, Qianqian Yu, Du Liu, Yanhui Zhou, and Jie Liu*. Selective nuclei accumulation of ruthenium(II) complex enantiomers that target G-quadruplex DNA,Journal of Inorganic Biochemistry 150 (2015) 90–99. IF= 3.44SCI一区    引用14次
  8. Dongdong Sun, Weiwei Zhang, Mengting Lv, Endong Yang, Qian Zhao, Weiyun Wang*. Antibacterial activity of ruthenium(II) polypyridyl complex manipulated by membrane permeability and cell morphology. Bioorg. Med. Chem. Lett. 25 (2015) 2068–2073.. IF:2.42  SCI二区  引用10次
  9. Dongdong Sun, Weiwei Zhang, Nuan Li, Endong Yang, Haiping Liu, Weiyun Wang.* Silver nanoparticles-quercetin Conjugation to siRNA against multidrug-resistant Bacillus subtilis for Effective Gene Silencing: In Vitro and in Vivo. Materials Science and Engineering C 63 (2016) 522–534. . IF: 3.42, SCI二区  引用1次
  10. Dongdong Sun, Nuan Li, Weiwei Zhang, Endong Yang, Zhipeng Mou, Zhiwei Zhao, Haiping Liu , Weiyun Wang*. Quercetin-loaded PLGA nanoparticles: a highly effective antibacterial agent in vitro and anti-infection application in vivo. J Nanopart Res( 2016)1 8:3-21. 2.1 IF: 2.1  SCI二区  引用6次
  11. Dongdong Sun, Zhipeng Mou, Nuan Li, Weiwei Zhang,Yazhe Wang, Endong Yang, Weiyun Wang*. Anti-tumor activity and mechanism of apoptosis of A549 induced by ruthenium complex[J]. J Biol Inorg Chem, 2016:1-12. IF: 2.495  SCI二区  引用4次
  12. Dongdong Sun,Weiwei Zhang, Endong Yang, Nuan Li,Haiping Liu, Weiyun Wang*. Investigation of antibacterial activity and related mechanism of a ruthenium(II) polypyridyl complex. Inorganic Chemistry Communications 56 (2015) 17–21.  IF= 1.77SCI三区   引用5次
  13. Dongdong Sun, Weizhang Wang, Jianwen Mao,Wenjie Mei,Jie  Liu(*),Imidazo [4,5f][1,10] phenanthroline derivatives as inhibitor of c-myc gene expression in A549 cells via NF-kappa B pathway,Bioorganic & Medicinal Chemistry Letters,2012.1.1,22(1):102–105. IF=2.442  SCI二区  引用27次
  14. Weiwei Zhang, Wenwen Yu, Xiaoyuan Ding, Chenyang Yin, Jing Yan, Endong Yang, Feng Guo, Dongdong Sun(*), Weiyun Wang(*). Self-assembled thermal gold nanorod-loaded thermosensitive liposome-encapsulated ganoderic acid for antibacterial and cancer photochemotherapy. Artif Cells Nanomed Biotechnol. 2019;47:406-419. IF=3.026  SCI二区   引用0次
  15. Weiwei Zhang, Zhipeng Mou, Yazhe Wang, Ying Chen, Endong Yang, Feng Guo, Dongdong Sun(*), Weiyun Wang(*). Molybdenum disulfide nanosheets loaded with chitosan and silver nanoparticles effective antifungal activities: in vitro and in vivo. Mater Sci Eng C Mater Biol Appl. 2019;97:486-497. IF=5.08  SCI一区   引用0次
  16. Lumin Yu, Fei Shang, Xiaolin Chen, Jingtian Ni, Li Yu, Ming Zhang, Dongdong Sun(*), Ting Xue(*). The anti-biofilm effect of silver-nanoparticle-decorated quercetin nanoparticles on a multi-drug resistant Escherichia coli strain isolated from a dairy cow with mastitis. PeerJ. 2018;6:e5711. IF=2.118  SCI二区   引用0次
  17. Hao Cheng, Zhipeng Mou, Weiyun Wang, Weiwei Zhang, Zhiyan Wang, Mingjun Zhang, Endong Yang, Dongdong Sun(*). Chitosan–catechin coating as an antifungal and preservable agent for postharvest satsuma oranges. Journal of Food Biochemistry. 2019;e12779. IF=1.552  SCI三区   引用0次

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